What are some of the physiological changes that occur in osteoporosis?

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What causes osteoporosis pathophysiology?

Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.

What happens if osteoporosis is left untreated?

Osteoporosis left untreated increases the likelihood of fractures. Simple actions such as sneezing or coughing, making a sudden turn, or bumping into a hard surface can result in a fracture. This can make you feel like you’re walking on eggshells and cause you to refrain from participating in activities that you enjoy.

Is sitting bad for osteoporosis?

“If you have low bone density, however, and you put a lot of force or pressure into the front of the spine — such as in a sit-up or toe touch — it increases your risk of a compression fracture.” Once you have one compression fracture, it can trigger a “cascade of fractures” in the spine, says Kemmis.

What are the two medications that may cause osteoporosis after long term use?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.

What foods are bad for osteoporosis?

7 Foods to Avoid When You Have Osteoporosis

  • Salt. …
  • Caffeine. …
  • Soda. …
  • Red Meat. …
  • Alcohol. …
  • Wheat Bran. …
  • Liver and Fish Liver Oil.
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What are the types of osteoporosis?

Two categories of osteoporosis have been identified: primary and secondary. Primary osteoporosis is the most common form of the disease and includes postmenopausal osteoporosis (type I), and senile osteoporosis (type II). Secondary osteoporosis is characterized as having a clearly definable etiologic mechanism.

What tests are used to diagnose osteoporosis?

To diagnose osteoporosis and assess your risk of fracture and determine your need for treatment, your doctor will most likely order a bone density scan. This exam is used to measure bone mineral density (BMD). It is most commonly performed using dual-energy x-ray absorptiometry (DXA or DEXA) or bone densitometry.

What is the mechanism of osteoporosis development?

The three main mechanisms by which osteoporosis develops are an inadequate peak bone mass (the skeleton develops insufficient mass and strength during growth), excessive bone resorption, and inadequate formation of new bone during remodeling, likely due to mesenchymal stem cells biasing away from the osteoblast and …